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Aspergillus flavus the most common grain mould fungi that results in acute form of aflatoxicosis and affects the liver and other organs leading to reduced growth rate and reproduction. The study investigated the effects of different levels of aflatoxin on growth rate, feed intake and plasma cholesterol levels of rabbits. The study had the following objectives; determine the effects of Aflatoxin on feed intake in New Zealand White rabbits; evaluate the effects of Aflatoxin on growth rate of New Zealand White rabbits; and assess the effects of Aflatoxins on the plasma cholesterol levels of New Zealand White rabbits. A Complete Randomized Design experiment was used with 16 New Zealand White grower rabbits in 4 treatments of (A): 0 ppb Aflatoxin concentration + concentrate, (B); 75 ppb Aflatoxin concentration + concentrate, (C): 150 ppb Aflatoxin concentration + concentrate and (D) 300 ppb Aflatoxin concentration + concentrate. All the rabbits were initially weighed at day 0 and weights recorded daily. A formulated feed rations of 650gms with four different levels of Aflatoxin (0, 75, 150 and 300ppb) were given to each group of rabbits each morning and the leftover weighed and recorded for a period of nine-week period. Animals were pre-treated with Wormazine hydro-soluble anthelminth, Aliseryl WSP Hydrosoluble mix of antibiotics and given vitamins. Feed intake was determined daily and blood samples collected at the onset and on every two weeks and taken to the laboratory for cholesterol levels analysis. Resulting data were entered into Microsoft Excel application and analysed using Genstat 14 to generate descriptive statistics and ANOVA, and results presented in tabular and graphical formats. The rabbits in Treatments B and C displayed a pronounced and sustained decline feed intake as the F = 48.36, p = 0.001 indicated significant differences in feed intake in the different aflatoxin concentrations. The control group achieved the highest net weight gain, averaging 1.1675 kg followed by Treatment A at 0.700 kg, Treatment B had a a negligible change, Treatment C recorded an average net loss of 0.3 kg, with F = 13.13, p = 0.001 indicating statistically significant differences in overall weight in the different aflatoxin concentrations. Control group achieved the highest average weekly weight gain (130 g/week), followed by Treatment A (73.3 g/week). Rabbits in Treatments B and C showed negligible net change, with an average weekly gain of only 5.86 g/week, effectively maintaining baseline weight rather than exhibiting meaningful growth. The F = 10.53, p = 0.001 indicated statistically significant differences in weight gain/loss in the different aflatoxin concentrations. The control group (0 ppb) exhibited a mean cholesterol level of 106.81 ± 1.07 mg/dL,treatments A (75 ppb aflatoxin) and B (150 ppb) maintained relatively stable cholesterol levels (105.63 ± 4.46 mg/dL and 112.94 ± 10.53 mg/dL, respectively).the control group (0 ppb) and Treatment A (75 ppb ) exhibited the lowest average LDL concentration at 60 mg/dL with means of 54.94 ± 4.08 mg/dL and 56.63 ± 1.36 mg/dL, respectively. In contrast, treatment B (150 ppb) showed moderately elevated LDL (63.13 ± 7.03 mg/dL), ranging between 55 and 70 mg/dL while those in Treatment C (300 ppb) displayed a pronounced increase, with a mean of 85.69 ± 14.22 mg/dL and individual values ranging from 65 to 95 mg/dL. The control group (0 ppb) exhibited the most stable HDL profile, with a mean of 35.44 ± 2.29 mg/dL and a narrow range (35–40 mg/dL), with Treatments A (75 ppb) and B (150 ppb) showing similar HDL levels (34.50 ± 1.91 mg/dL and 34.44 ± 2.01 mg/dL, respectively. The study clearly demonstrates that dietary aflatoxin B₁ has significant and dose-dependent negative effects on New Zealand White rabbits across three critical domains: feed intake, growth performance, and plasma lipid metabolism. The study calls for the effective management of aflatoxin contamination in rabbit production through holistic, integrated approach and stringent mycotoxin control.